Focusing and imaging with increased numerical apertures through multimode fibers with micro-fabricated optics

The use of individual multimode optical fibers in endoscopy applications has the potential to provide highly miniaturized and noninvasive probes for microscopy and optical micromanipulation. A few different strategies have been proposed recently, but they all suffer from intrinsically low resolution related to the low numerical aperture of multimode fibers. Here, we show that two-photon polymerization allows for direct fabrication of micro-optics components on the fiber end, resulting in an increase of the numerical aperture to a value that is close to 1. Coupling light into the fiber through a spatial light modulator, we were able to optically scan a submicrometer spot (300 nm FWHM) over an extended region, facing the opposite fiber end. Fluorescence imaging with improved resolution is also demonstrated.Comment: 5 pages, 3 figure

Nanoscale electron-beam-driven metamaterial light sources

Free-standing and fiber-coupled photonic metamaterials act as nanoscale, free-electron-driven, tuneable light sources: emission occurs at wavelengths determined by structural geometry in response to electron-beam excitation of metamaterial resonant plasmonic modes

The old anticentre open cluster Berkeley 32: membership and fundamental parameters

We have obtained medium-low resolution spectroscopy and BVI CCD imaging of Berkeley 32, an old open cluster which lies in the anticentre direction. From the radial velocities of 48 stars in the cluster direction we found that 31 of them, in crucial evolutionary phases, are probable cluster members, with an average radial velocity of +106.7 (sigma = 8.5) km/s. From isochrone fitting to the colour magnitude diagrams of Berkeley 32 we have obtained an age of 6.3 Gyr, (m-M)0 = 12.48 and E(B-V) = 0.10. The best fit is obtained with Z=0.008. A consistent distance, (m-M)0 ~= 12.6 +/- 0.1, has been derived from the mean magnitude of red clump stars with confirmed membership; we may assume (m-M)0 ~= 12.55 +/- 0.1. The colour magnitude diagram of the nearby field observed to check for field stars contamination looks intriguingly similar to that of the Canis Major overdensity.Comment: MNRAS, in press. Degraded resolution for Fig.

Near Infrared Spectroscopy of High Redshift Active Galactic Nuclei. II. Disappearing Narrow Line Regions and the Role of Accretion

We present new near infrared spectroscopic measurements for 29 luminous high-z quasars and use the data to discuss the size and other properties of the NLRs in those sources. The high resolution spectra have been used to carefully model the Fe II blends and to provide reliable [O III], Fe II and Hb measurements. We find that about 2/3 of all high luminosity sources show strong [O III] lines while the remaining objects show no or very weak such line. While weak [O III] emitters are also found among lower luminosity AGN, we argue that the implications for very high luminosity objects are different. In particular, we suggest that the averaging of these two populations in other works gave rise to claims of a Baldwin relationship in [O III] which is not confirmed by our data. We also argue that earlier proposed relations of the type R_NLR \propto L_[O III]^{1/2}, where R_NLR is the NLR radius, are theoretically sound yet they must break down for R_NLR exceeding a few kpc. This suggests that the NLR properties in luminous sources are different from those observed in nearby AGN. In particular, we suggest that some sources lost their very large, dynamically unbound NLR while others are in a phase of violent star-forming events that produce a large quantity of high density gas in the central kpc. This gas is ionized and excited by the central radiation source and its spectroscopic properties may be different from those observed in nearby, lower luminosity NLRs. We also discuss the dependence of EW(Hb) and Fe II/Hb on L, M_BH, and accretion rate for a large sample of AGNs. The strongest dependence of the two quantities is on the accretion rate and the Fe II/Hb correlation is probably due to the EW(Hb) dependence on accretion rate. We show the most extreme values measured so far of Fe II/Hb and address its correlation with EW([O III]).Comment: 10 pages (emulateapj), 9 figures. Accepted by Ap

Electron-beam-driven nanoscale metamaterials light sources

Nanoscale light (ultimately laser) and surface plasmon (ultimately 'spaser') sources for numerous potential nanophotonic applications have generated and continue to generate considerable research interest, with a variety of optically- and electrically-pumped sources recently demonstrated. We show experimentally that beams of free electrons can be used to induce light emission from nanoscale planar photonic metamaterials, at wavelengths determined by both the metamaterial design parameters and the electron energy

Drug delivery applications of three-dimensional printed (3DP) mesoporous scaffolds

Mesoporous materials are structures characterized by a well-ordered large pore system with uniform porous dimensions ranging between 2 and 50 nm. Typical samples are zeolite, carbon molecular sieves, porous metal oxides, organic and inorganic porous hybrid and pillared materials, silica clathrate and clathrate hydrates compounds. Improvement in biochemistry and materials science led to the design and implementation of different types of porous materials ranging from rigid to soft two-dimensional (2D) and three-dimensional (3D) skeletons. The present review focuses on the use of three-dimensional printed (3DP) mesoporous scaffolds suitable for a wide range of drug delivery applications, due to their intrinsic high surface area and high pore volume. In the first part, the importance of the porosity of materials employed for drug delivery application was discussed focusing on mesoporous materials. At the end of the introduction, hard and soft templating synthesis for the realization of ordered 2D/3D mesostructured porous materials were described. In the second part, 3DP fabrication techniques, including fused deposition modelling, material jetting as inkjet printing, electron beam melting, selective laser sintering, stereolithography and digital light processing, electrospinning, and two-photon polymerization were described. In the last section, through recent bibliographic research, a wide number of 3D printed mesoporous materials, for in vitro and in vivo drug delivery applications, most of which relate to bone cells and tissues, were presented and summarized in a table in which all the technical and bibliographical details were reported. This review highlights, to a very cross-sectional audience, how the interdisciplinarity of certain branches of knowledge, as those of materials science and nano-microfabrication are, represent a growing valuable aid in the advanced forum for the science and technology of pharmaceutics and biopharmaceutics

Design of a beamline for soft and deep lithography on third generation synchrotron radiation source

ELETTRA is a third generation synchrotron radiation source. The energy spectrum allows the design of beamlines suitable for x-ray lithography from soft to hard x-ray wavelengths. An appropriate lithographic window for micro- and nanofabrication can be obtained by a combination of selected filters and mirrors. As the beamline is interfaced to a vertical x-ray stepper, a uniformity in the beam intensity better than 3% (3σ) in the horizontal direction has to be reached. The present beamline is designed by taking into account the main factors which can affect the beam quality, namely, thermal loading on mirrors and filters, slope errors, and surface roughness of the mirrors. The resulting lithographic resolution at soft x-ray wavelengths is better than 100 nm

A Composite Index for Measuring Stock Market Inefficiency

Market inefficiency is a latent concept, and it is difficult to be measured by means of a single indicator. In this paper, following both the adaptive market hypothesis (AMH) and the fractal market hypothesis (FMH), we develop a new time-varying measure of stock market inefficiency. The proposed measure, called composite efficiency index (CEI), is estimated as the synthesis of the most common efficiency measures such as the returns' autocorrelation, liquidity, volatility, and a new measure based on the Hurst exponent, called the Hurst efficiency index (HEI). To empirically validate the indicator, we compare different European stock markets in terms of efficiency over time